Whereas LB pathology is found in virtually all cases of sPD, it was found only inconsistently in PINK1/PRKN PD (6/17 genetically confirmed PRKN PD, and trace amounts in 1/1 PINK1), suggesting that α-synuclein may be a minor player in these cases [53, 56]. This evidence concerns the gene PRKN and Parkinson disease.