In 2019, Yeo et al. showed that serum induces tumor invasion and VM formation through the EphA2/VE-cadherin/AKT pathway, and upregulates the expression levels of VE-cadherin, matrix metalloproteinase-2 (MMP-2), and laminin subunit 5 γ-2 (LAMC2) protein [4]. The gene discussed is CDH5; the disease is neoplasm.