EPHA2 and neoplasm: In glioblastomas, when there is insufficient blood supply in the tumor, glioblastoma stem-like cells express pro-vascular molecules such as EGFR, endothelium-associated genes including EphA2, Laminin 5γ2, and Neuropilin-2, leading to the de novo formation of blood vessels with GSCs as the lining cells of the luminal surface [41].