Furthermore, another important finding in this study was that lncARSR activated the IRS2/AKT pathway to elevate lipid accumulation in vivo and in vitro, accompanied by increased expression of Fasn, Scd1 and GPA, and accelerate NAFLD progression through inhibition of YAP1 phosphorylation. The gene discussed is IRS2; the disease is metabolic dysfunction-associated steatotic liver disease.