Stem cell factor (SCF) binds to c-Kit to activate PI3K/Akt, SRC, PLCγ1, JAK/STAT, RAS/MAP kinase, Wnt/β-catenin and Notch pathways, which drive the proliferation, survival, migration and stemness phenotype of cancer [8, 19–22]. The gene discussed is KITLG; the disease is cancer.