In comparison, suppression of phospho-PHBY259 by transfection with pD-PHBY259F-HA in c-Kit-overexpressing tumor cells, such as SKOV3_c-Kit, SKOV3GL-G4 or KURAMOCHI cells, reduced the levels of β-catenin and ABCG2 (Fig. 6c & Suppl. The gene discussed is KIT; the disease is neoplasm.