Anti-VEGF class events were infrequent, with GI perforation reported in 0.9% of patients (grouped term), GI fistula in 1.2%, fistula from other origin in 0.8%, and jaw osteonecrosis and posterior reversible encephalopathy syndrome in 0.4% each. Here, VEGFA is linked to Posterior Leukoencephalopathy Syndrome.