LYZ and kidney disorder: LZM is an ideal renal-targeting carrier for several reasons: first, as a low-molecular-weight protein, it can freely filter the glomeruli and be effectively absorbed by PTECs of the kidneys [23], but other parts of the body do not have this specific structure, and it has been widely used in other drug–LZM conjugates for the treatment of renal disease [24,25]; secondly, LZM has high safety and can be injected and taken orally.