Evaluating the relationship between high plasma levels of FVIII and the risk of recurrent venous thrombosis, Kyrle et al. [107] observed that this relation was nonlinear, and the risk of recurrent thrombosis for patients with a FVIII level above 90th percentile was 7.4 times higher than individuals with lower levels. The gene discussed is F8; the disease is Venous thrombosis.