Knockout of the antioxidant enzyme glutathione peroxidase-3 (GPX-3) results in increased platelet-dependent thrombosis in mice [66], whereas mice overexpressing the GPX-1 isoform were protected from platelet hyperactivity and age-dependent increased susceptibility to experimental venous thrombosis after ligation of the inferior vena cava (IVC) [67]. This evidence concerns the gene GPX3 and Venous thrombosis.