CD40LG and hyperinsulinemic hypoglycemia, familial, 4: Platelet NOX2 is upregulated and plasma levels of soluble P-selectin and soluble CD40L (sCD40L)are elevated in obese patients who have elevated oxidative stress and an increased risk of DVT [52], while the plasma levels of these proteins are decreased in women with hereditary deficiency of NOX2 [53].