The levels of cancer stemness-related genes (ABCG2, BMI1, NANOG, KLF4, and OCT4) mRNA and proteins (ABCG2, Oct4, Bmi-1, and CD44) expression were downregulated with treatment of STF-31 in HBx-expressing MHCC-97H cells (Figure 4A,B). Here, POU5F1 is linked to cancer.