In healthy pancreas, PSCs are quiescent and are characterized by lipid droplets containing vitamin A. PSCs become activated during cancer transformation, at which point they lose their lipid droplets and produce excessive ECM proteins, including collagen, fibronectin, laminin, α-smooth muscle actin (α-SMA), growth factors (such as platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF)), and several cytokines [7]. This evidence concerns the gene VEGFA and cancer.