CD34 and diabetes mellitus: As displayed in Table 1, the use of human peripheral blood CD34+ cells or human adrenal H295R cells, consistent with 3T3-L1 adipocytes, HepG2 hepatocytes, and HUVECs as well as INS-1E beta-cells were some of the in vitro models employed to assess the comparative effects of metformin in ameliorating diabetes-related abnormalities.