Consistently, activation of SIRT1 and AMPK, together with a reduction of intracellular lipid overload, improvement of glucose transport, amelioration of ROS, and attenuation of pro-inflammatory/apoptotic markers such as NF-κB and BAX expression were the predominant mechanism by which metformin and resveratrol could control diabetes-associated complications in vitro [33,34,35,36,37,38,39,40,41]. This evidence concerns the gene BAX and diabetes mellitus.