NOS3 and heart failure: Saxagliptin prevented vascular remodeling and oxidative stress in T2DM mice by abolishing nicotinamide adenine dinucleotide phosphate NAD(P)H oxidase-driven endothelial nitric oxide synthase (eNOS) uncoupling [19] and prevented increased coronary artery stiffness and collagen deposition in a mini swine model of heart failure, partly by decreasing AGEs [20].