Moreover, reduced expressions of GLAST and/or GLT-1 were reported in models of SCA1, SCA7, and SCA28 in which the mutant genes were selectively expressed in astrocytes [46,56,72], indicating that the genetic alterations underlying some forms of ataxia may directly interfere with the astrocytes-mediated glutamate uptake. This evidence concerns the gene SLC1A3 and Ataxia.