Specifically, the episodic ataxia 6 (EA6)-related point mutation P290R in the SLC1A3 gene (encoding GLAST) was shown not only to reduce the number of GLAST transporters on the surface of mammalian cells and impair their glutamate uptake but also to cause the appearance of larger anion currents with or without the administration of external glutamate [95]. Here, SLC1A3 is linked to episodic ataxia type 6.