Along the same line, a novel kind of synthetic antisense long non-coding RNAs capable of upregulating the expression of specific genes of interest, called SINEUPS, has been very recently shown to rescue defective frataxin expression and activity in a human cellular model of Friedreich’s Ataxia [125]: it will be interesting to evaluate in the future whether this approach can target both neuronal and non-neuronal cells. This evidence concerns the gene FXN and Friedreich ataxia.