IKBKB and cerebellar ataxia: Furthermore, astrogliosis induced by the activation in astrocytes of IKK2, enzymatic complex involved in propagating the cellular response to inflammation, resulted in a strong downregulation of both GLAST and GLT-1, indicating that IKK2 per se may be a negative regulator of their expression in vivo and may directly mediate the local imbalance of glutamate homeostasis and neuronal excitotoxicity, at least in inflammatory cerebellar ataxias [78].