Positive ANA (in 24–53% of patients with PSC), SMA (13–20% of patients with PSC), anticardiolipin antibodies (up to 66% of cases), and rheumatoid factor; increased hepatic and urinary copper; and decreased serum ceruloplasmin may be encountered in PSC, though are not specific [1]. The gene discussed is BTG3; the disease is pancreatic serous cystadenoma.