Antidiabetic drugs, such as SGLT2 inhibitors and GLP-1 RA, have shown their improved overall survival in T2D patient by a variety of global large population studies (EMPA-REG outcome [60], CANVAS program [112], DECLAIR [113], CREDENCE [114], and DAPA-HF [62]). Here, GLP1R is linked to type 2 diabetes mellitus.