DS, which can be fatal in 2.5–30% of cases in its moderate or severe forms, is characterized by the presence of a large number of inflammatory, differentiated leukemic cells in the bloodstream that synthesize and secrete chemokines and cytokines, triggering a so-called “cytokine storm.” We previously showed that MCP-1, IL-1β and TNFα were secreted in a TG2-quantity-dependent manner in differentiated NB4 cell lines. Here, TNF is linked to Dravet syndrome.