Other factors linked to inflammatory/trophic CRC progression (IL8/CXCL8, GROβ/CXCL2, as agonists of G-protein coupled receptors; PGE2 produced by PTGS2 activation; EGF as the prototype EGFR tyrosine-kinase agonist) were also tested as potential PTGS2 inducers [1,24,25,26]. The gene discussed is PTGS2; the disease is colorectal carcinoma.