SPI1 and adult acute monocytic leukemia: Mechanistically, NONO binds Spi‐1/PU.1 via its RNA binding domain, and NONO splicing function is interfered by this binding.33 In human acute monocytic leukaemia THP1 cells, NONO is strongly expressed, while knock‐down of NONO slightly promotes cell proliferation but strongly inhibits motricity and invasion.