In 2016, the TFE3‐NONO RCC morphology was described for the first time, showing subnuclear vacuoles that lead to frequent distinctive suprabasal nuclear palisading.84 Furthermore, fusion of TFE3 and NONO is associated with the loss of normal TFE3/NONO transcripts. This evidence concerns the gene TFE3 and renal cell carcinoma.