The LIMK family consists of LIMK1 and LIMK2, which belongs to the serine protein kinase, and associated with actin polymerization and microtubule depolymerization.29 The expression of LIMK1 was mainly seen in the cytoplasm and can freely shuttle between normal nucleus and cytoplasm.9 The expression of LIMK was elevated in many kinds of tumours, especially highly invasive malignancies. This evidence concerns the gene LIMK2 and neoplasm.