CFL1 and Familial prostate cancer: Cofilin can be inactivated by LIMK1 when its Ser3 site was phosphorylated.12 Inactivated cofilin lost the ability of binding to actin filaments which improved the stability of F‐actin, resulting in the change of actin cytoskeleton.13 Several studies have now confirmed that the expression of LIMK1 is consistently elevated in the many kinds of tumours including breast cancer,6, 14 ovarian cancer,15, 16 colon cancer17, 18 and gastric cancer.19, 20 However, researchers have paid little attention to the role of LIMK1 in prostate cancer.