Several studies have reported that LIMK can promote the invasive and metastatic ability of tumours.8, 17 What is more, it also participated in many kinds of biological behaviours including angiogenesis, proliferation, cell cycle and migration.14, 21, 22, 23 Thus, LIMK1 has great potential to be a therapeutic target to prevent the invasion and metastasis of PCa. The gene discussed is LIMK1; the disease is posterior cortical atrophy.