First, all three samples showed ALK, APC, CSF1R, EGFR, FGFR1, FGFR3, FLT3, KDR, HRAS, PDGFRA, RET, and TP53 mutations with high frequency, which were considered indispensable for tumor progression in this SBA model. The gene discussed is TP53; the disease is neoplasm.