LAMB2 and open-angle glaucoma: Trabecular meshwork tissue consists of various extracellular matrix (ECM) proteins, including collagen (types I, III, IV and V), proteoglycans and laminin.40 Changes in ECM are thought to have a role in the increased out‐flow resistance of the TM in POAG.41 Activation of the Wnt signalling pathway in humans has been shown to promote fibrosis of various organs.42 We have been suggested that down‐regulation of Wnt/β‐catenin signalling pathway by NPCE EVs would reduce collagen protein expression in TM cells.