To further understand the mechanism of KRT10 deregulation in the pathogenesis of psoriasis, we analysed online data in the chromatin co‐immunoprecipitation database (http://ddbj.nig.ac.jp/) via the Chip‐Atlas (http://chip-atlas.org/) and found that Tp63 could activate the transcription of KRT10 via targeting its promoter region. Here, KRT10 is linked to psoriasis.