As the type I keratin chaperone of K6, KRT16 is involved in intermediated filament heterodimer formation.48 This KRT6/ KRT16 keratin pair is not found within normal epidermis, but is induced within hyperplasia cells, including psoriatic epidermis.49, 50 Nevertheless, at the beginning of final differentiation, the keratinocytes first move up to become mitotic cells and then convert to keratin pair KRT1‐KRT10 expression.51 Within hyperplasia conditions, such as psoriasis, down‐regulation of KRT10 occurs in keratinocytes. Here, KRT16 is linked to psoriasis.