As we have mentioned, the reduction of KRT10 and other differentiation markers is one of the characteristics of psoriasis.27 To investigate whether the ozone therapy improves psoriasis through KRT6/10, the levels of KRT6 and KRT10 in normal skin, psoriasis lesions with or without the ozone therapy were examined by immunohistochemical (IHC) staining. The gene discussed is KRT72; the disease is psoriasis.