These alterations can be manifested as increased KRT10 and decreased KRT6, respectively.52 Consistent with previous studies, we observed up‐regulated KRT6 and down‐regulated KRT10 protein levels in psoriasis lesions of patients and IMQ mouse models; in the meantime, ozone treatment significantly reduced the KRT6 while increased the KRT10 levels. This evidence concerns the gene KRT10 and psoriasis.