Adaption processes to culturing conditions or clonal selection of small proportions of tumor cells [6,92,93] may explain the further mesenchymal transition of cell lines Adcarc1508, TCC1509, Adcarc1511.1, Metadcarc1511.2 and Metadcarc1511.3, which is characterized by gains of vimentin and losses of pan-CK expression. This evidence concerns the gene VIM and neoplasm.