The AUC value of 0.823 for APEX1 (95% CI: 0.765 to 0.881; p<0.001) was significantly higher than the AUC value of 0.7869 for AFP in HCC tumor samples (95% CI: 0.7295 to 0.8443, p<0.0001) as shown in Figure 4B. This evidence concerns the gene AFP and neoplasm.