PARP1 is involved in many important biological processes and plays important roles in many diseases including inflammation23 and tumours.24, 25 PARP1 is closely related to DNA damage repair under stress conditions.26 PARP1 is cut by caspase3 in apoptosis,11 which eliminates the enzymatic activity of PARP1, thus completing the biological process of apoptosis.27 The stability of single‐ or double‐stranded DNA is reduced or broken in conditions of oxidative stress damage, which activates PARP1. The gene discussed is PARP1; the disease is neoplasm.