Smurf2 also affects embryonic development, cell polarity, cell migration and bone homeostasis.17 In the past 10 years, the ubiquitin‐proteasome system has been widely studied in the cardiovascular field, including its role in atherosclerosis, familial cardiac proteinopathies, idiopathic dilated cardiomyopathies and myocardial ischaemia.18 However, the role and mechanism of Smurf2 in endothelial cell injury induced by oxidative stress remain unclear. Here, SMURF2 is linked to atherosclerosis.