PGAM1 is usually upregulated in TP53‐deficient tumors and promotes tumor growth by coordinating glycolysis and biosynthetic metabolism.16 PGAM1 can promote proliferation and metastasis of tumors cells in malignant tumors such as small cell lung cancer, pancreatic ductal adenocarcinoma, and oral squamous cell carcinoma by playing a tumor‐promoting role.17, 18, 19 However, there have been no reports on the function of circ‐PGAM1 in cancers. This evidence concerns the gene PGAM1 and oral cavity squamous cell carcinoma.