MTOR and Familial prostate cancer: Liu et al reported that PGAM1 promoted epithelial–mesenchymal transition (EMT) of pancreatic ductal adenocarcinoma cells through activation of the Wnt/β signaling pathway and acted as a downstream target of PI3K/Akt/mTOR to promote malignant progression of pancreatic ductal adenocarcinoma.18 Furthermore, Wen et al45 reported that PGAM1 was highly expressed in prostate cancer tissues and cell lines and that PGAM1 silencing inhibited cell proliferation, migration, and migration and promoted cell apoptosis.