This result is consistent with the study by Bernstein et al.31 After the cultured cells were stimulated by serum, CDC5L rapidly translocated from the cytoplasm to the nucleus, with a concamitant increase in phosphorylation.31 Considering the tumor‐promotion function of CDC5L in various types of tumors and the presence of the miR‐542‐3p binding site predicted by bioinformatics database, we hypothesized that CDC5L might be involved in the regulatory network of circ‐PGAM1/miR‐542‐3p. The gene discussed is PGAM1; the disease is neoplasm.