AFP‐L3%, a tumor biomarker used for HCC diagnosis is an AFP‐isoform that reflects changes in the carbohydrate chain; further, AFP‐L3% is more specific than AFP for HCC diagnosis.7, 17, 21 In our research, we assessed the value of combining AFP and AFP‐L3% for HCC diagnosis based an original study and literature review. Here, AFP is linked to neoplasm.