AFP and hepatocellular carcinoma: As most of markers present defective sensitivity, numerous studies indicate that it may be advisable to apply several biomarkers in subjects with HCC.7, 8 In the present meta‐analysis, the overall sensitivity, specificity, and AUC of AFP were 0.59, 0.83, and 0.7322; those of AFP‐L3% were 0.56, 0.90, and 0.8357; and those of AFP + AFP‐L3% were, respectively, 0.71, 0.79, and 0.7513.