AFP and neoplasm: Lens culinaris agglutinin‐reactive fraction of AFP (AFP‐L3%), an AFP‐isoform, has been considered an effective tumor marker for HCC diagnosis.4, 5 In the recent studies, AFP‐L3% has proved effective for establishing an early diagnosis of HCC,6, 7 but it is still a controversial issue for the ability of the AFP + AFP‐L3% for HCC diagnosis in previous studies.