HIF1A and Parkinson disease: The first step to calculate our results in our experiment is to investigate whether the HIF-1α/miR-128-3p axis affected hippocampal neurodegeneration by regulating Axin1 with the help of screening of the GEO database (PD-related microarray data GSE7621) revealed that Axin1 was one of the most upregulated DEGs in PD (Supplementary Figure 1A).