Additionally, when the age, gender, history of smoking, hypertension and type 2 diabetes, the serum concentration of CK, LDH, CRP and ESR were adjusted, the adjusted hazard ratio for serum 25(OH)D was 0.730 (95% confidence interval 0.578-0.992, P = 0.008) (Table 3). This evidence concerns the gene ESR1 and type 2 diabetes mellitus.