PCSK6 and Familial prostate cancer: Additionally, miR-124 has been shown to inhibitthe proliferation and migration of prostate cancer cells via the PACE4 pathway(Kang et al., 2014).However, few studies have elucidated the effect of PACE4 on the pathogenesis of OA.Malfait et al. (2012) evaluated the association of 10PACE4 gene polymorphisms with the risk of symptomatic knee OAin a Caucasian cohort of 600 OA cases and 432 controls.