MMP2 and neoplasm: Numerous reports indicated that STAT-3 activation plays the most significantfunction in tumor cell invasion, and its inhibition reduces invasion (Barré et al., 2003; Ma et al., 2007; Yakata et al., 2007;Xiong et al., 2008;Zhao et al., 2008).The expression of matrix metalloproteinase (MMP)-2 and MMP-1 is regulated bySTAT-3 activation that initiates tumor invasion and metastasis (Xie et al., 2004; Itoh et al., 2005).