By using Ratjadone A or Leptomycin B, inhibition of exportin 1 hinders nuclearimport of STAT-3, as well as diminishing intensities of STAT-3 phosphorylationand STAT-3-facilitated transcription, which leads to increased apoptosis (Liu et al., 2005).Rajtadone-A was tested on N2A (mouse neuroblastoma) cell lines, while LeptomycinB was examined on human lung carcinoma cell lines (A549). The gene discussed is STAT3; the disease is neuroblastoma.