STAT3 and neoplasm: Inhighly metastatic cells, invasiveness of the tumor cells is suppressed byobstruction of activated STAT-3, while metastasis of cutaneous squamous cellcarcinoma is associated with overexpression of phosphorylated STAT-3 (Suiqing et al., 2005).Tissue inhibitors of metalloproteinase hinders the activity ofmetalloproteinases, which are upregulated by STAT-3, and decrease invasivenessin certain cancer cells (Dien etal., 2006).