STAT3 and cancer: EMT is the binding of epithelial cells with mesenchymal cancer-associatedfibroblasts (CAFs), which results in loss of adhesion among cells, causing tumorprogression (Larue and Bellacosa, 2005).In cancers mediated by STAT-3, EMT gets involved in cancer progression by theIL-6 and JAK-STAT-3 pathway.