STAT3 and neoplasm: STAT-3activation was also associated with metastasis of human melanoma to brain (Xie et al., 2006).Moreover, VEGF and TWIST, another mediator of tumor metastasis, weresynchronized by STAT-3 in an in-vivo analysis, whereaschemoresistance, angiogenesis, and cell survival were induced in anin-vitro study (Chenget al., 2008)