CIDEC and obesity due to melanocortin 4 receptor deficiency: Although those data warrants further confirmation at the protein level, it is worth noting that perilipin2 is usually found upregulated in obesity.41,42 More strikingly, multiple studies demonstrated that perilipin2 knockout mice developed a highly reproducible obesity-resistant phenotype43-47 associated with modulation of the gut microbiota composition.48 Finally, Cidec expression was reduced in obese individuals and upregulated following bariatric surgery-induced weight loss.49,50