PLCG2 and dementia: This reduction in effect may be produced by chronical exposure of microglia to deleterious insult undermining the protective function of microglia including the protective effect given by p.P522R in PLCG2. Understanding the pathways underlying the protective effect of PLCG2 and its buffering properties may help to develop therapeutic targets which can counteract this progressive collapse of the protection delaying or even preventing the beginning of the dementia stage.