VCP and frontotemporal dementia: As with GRN and C9orf72, other FTD genes, including TANK-binding kinase 1 (TBK1), Optineurin (OPTN), sequestosome (SQSTM1), and Valosin Containing Protein (VCP), have been linked to neuroinflammation and microglial function, because these genes can regulate one of the crucial regulators of glial activation and neuroinflammation, the nuclear factor-kappa beta (NF-κβ) [22].