Importantly, the statistical difference found for this variant between the MCI samples and the population-based studies further support the protective effect of PLCG2. However, p.P522R did not modulate the cognitive decline in any of the neuropsychological tests explored in the population-based samples (supplementary table 5, supplementary Figs. 3–5, online resource). Here, PLCG2 is linked to Mental deterioration.