APOE and Mental deterioration: In the same cohorts, the APOE-ε4 allele was, as expected, associated with accelerated cognitive decline (χ2 (2) = 138.33, p = 9.27 × 10–37, supplementary Table 2, online resource), but there was no statistically significant interaction between APOE-ε4 and p.P522R (χ2 (2) = 2.87, p = 0.238, supplementary table 4, online resource).