Chronic uncontrolled stress is a major cause of depression, which activates the innate immune system in the peripheral nervous system and CNS, and leads to the activation of caspase-1 by the NLRP3 inflammasome interacting with ASC and participates in the production of inflammatory cytokine processes, such as IL-18 and IL-1β [24, 25]. Here, IL1B is linked to major depressive disorder.