Dennis and colleagues [11] observed a supra-multiplicative effect for all alcohol excluding wine, among 33 cancer survivors with BRCA2 pathogenic germline gene variant compared to 814 survivors without BRCA2 pathogenic germline gene variant (COR 2.15, 95%CI 1.03,4.49); effects were not observed for all alcohol including wine, or wine alone [11]. The gene discussed is BRCA2; the disease is cancer.