BRCA1 and breast carcinoma: Kim and colleagues [27] assessed folic acid, B6, and B12 supplementation and observed that ever-use of a prenatal supplement was associated with reduced likelihood of breast cancer for 400 women with BRCA1/2 pathogenic germline gene variants (OR 0.57, 95%CI 0.34,0.95), when adjusting for age and BRCA1/2 pathogenic germline gene variant.