Notably, some studies demonstrated no association between alcohol intake and breast cancer risk among women with BRCA1/2 pathogenic germline gene variants collectively [15, 19, 31], while others observed a reduction in risk with alcohol intake in women with BRCA1 pathogenic germline gene variants [16, 23] and BRCA2 pathogenic germline gene variants [22]. The gene discussed is BRCA1; the disease is breast cancer.