Similarly, Moorman and colleagues [23] case-only study observed a significant, but weak effect of alcohol intake among 283 breast cancer survivors with BRCA1 pathogenic germline gene variant compared to 891 survivors without BRCA1 pathogenic germline gene variant (interaction risk ratio(IRR) 0.65, 95%CI 0.48,0.90) when adjusting for age and site of data collection. The gene discussed is BRCA1; the disease is breast carcinoma.