In contrast, Qian and colleagues [28] case-control study observed significant associations between a higher body mass index (BMI) and premenopausal ovarian cancer incidence, for both self-reported BMI (among 102 cases out of 7516 women with BRCA1/2 pathogenic germline gene variants) and a calculated BMI genetic score (BMI-GS; among 967 cases out of 22,588 women with BRCA1/2 pathogenic germline gene variants) based on a Mendelian Randomization approach. The gene discussed is BRCA1; the disease is ovarian cancer.