We consider the following factors limitations of the current state of evidence: small number of studies for both ovarian and breast cancer risk in this high risk population, especially when considering the available large epidemiological studies that have established associations of lifestyle factors among the general population; heterogeneity in methods to evaluate lifestyle factors; inconsistent confounding factors; no data evaluating hormone receptor status; limited data evaluating by gene variant and menopausal status. The gene discussed is NR4A1; the disease is breast cancer.