BRCA1 and breast cancer: Nkondjock and colleagues [31] assessed macro/micronutrient intake, alcohol, and coffee and found that among 89 women with BRCA1/2 pathogenic germline gene variants collectively, total energy intake > 2339 kcals/day was associated with nearly tripling breast cancer risk (HR 2.76, 95%CI 1.10,7.02; p-trend = 0.026), when adjusting for age, maximum lifetime BMI, and PA [31].