TLR4 and chronic myelogenous leukemia, BCR-ABL1 positive: In the present study, lipopolysaccharide (LPS) was utilized to trigger inflammation in CML k562 cells and the role of SIRT1 as well as that of the Toll-like receptor 4 (TLR4)–nuclear factor κ B (NFκB)–reactive oxygen species (ROS) signaling axis in inflammation was investigated.