Through repression of Skp2, physcion 8-O-β-glucopyranoside, escitalopram oxalate, curcumin, butylidenephthalid blocked cell cycle, inhibited proliferation, induced apoptosis, therefore attenuated the cell viability of glioma cells or in mice models [12, 31–34]. This evidence concerns the gene SKP2 and central nervous system cancer.