To determine whether IFN-γ signalling through Stat1 is also needed for the induction of p16Ink4a, p21Cip1, senescence and the control of endogenous cancers that are destroyed by strong T cell responses, we treated RT2 mice by the combination of anti-PD-L1 and anti-LAG-3 mAbs and adoptive T cell transfer (AT), with TH1 cells specific for a tumour associated antigen (TAA) in the SV40-Tag protein31 (Supplementary Fig. 7a). This evidence concerns the gene IFNG and cancer.