As ICB induced a similar immune infiltrate in RT2-cancers and in Stat1- and Cdkn2a-deficient RT2-cancers (Supplementary Fig. 6a–c), the data strongly suggest that senescence induction in the cancer cells was a prerequisite for tumour cell clearance by TH1 cells and IFN-γ-activated type I macrophages25,31,36–39. The gene discussed is CDKN2A; the disease is cancer.