CD8A and neoplasm: Indeed, the tumours controlled by ICB showed the established features of the TH1-mediated clearance mechanism, as β2-microglobulin was strongly expressed (Supplementary Fig. 4c, d) and as the tumours were infiltrated by CD3+CD8− T cells and F4/80+ and MHC class II+ activated macrophages (Supplementary Fig. 6a–c).