Immune histology showed that ICB also failed to induce senescence in Cdkn2a-deficient RT2-cancers as they displayed a Ki67+p16Ink4a−, pHP1γ−, H3K9me3−, SA-β-gal− phenotype (Fig. 1b, c and Fig. 2b–d). Here, CDKN2A is linked to cancer.