Immune histology revealed that the rapidly growing RT2.CRISPR-Cdkn2a-cancer cells had a Ki67+, p16Ink4a−, pHP1γ−, SA-β-gal− proliferative phenotype, but were positive for H3K9me3 (Fig. 1b, c and Fig. 2b–d). Here, MKI67 is linked to cancer.