To evaluate the clinical and translational relevance of PIK3CD-AS2 in LUAD and validated PIK3CD-AS2/YBX1/p53 axis in vivo, we established 12 representative LUAD patient-derived tumor xenograft (PDTX) models, of which tumors originated from six p53 wild-type surgical samples. This evidence concerns the gene TP53 and neoplasm.