KLF4 and myeloid sarcoma: KLF4 is also involved in pro-inflammatory activation of classically activated M1 macrophages, and regulates the polarization of pro-inflammatory M1 macrophages to anti-inflammatory M2 macrophages which are found to play major role in EAE/MS pathogenesis (Feinberg et al., 2005; Liao et al., 2011).