ABCG2 and gout: This hypothesis is further supported by the observation that the effect size of ABCG2 on urate in Europeans and Japanese is 58% and 73% that of SLC2A9, the most influential urate locus [4, 31], respectively, yet the effect size of ABCG2 on gout is consistently larger than that of SLC2A9 [4, 5, 32].