The observation that colchicine is able to rescue the 141K trafficking defect [23], the proposal that autophagy machinery and the inflammasome interact in the innate immune response [27], and evidence for association of ABCG2 rs2231142 with gout in the presence of HU in East Asian populations [28–30], suggests that ABCG2 may be important in gout beyond its established role in elevating urate levels. This evidence concerns the gene ABCG2 and gout.