BRAF and diffuse astrocytoma: Pleomorphic xanthoastrocytoma (40-80%) [46, 68, 85, 191], diffuse astrocytoma (30-40%) [190, 191] and ganglioglioma (25-45%) [85, 123, 164, 191] frequently harbor BRAF p.V600E, while in pilocytic astrocytoma (5-10%) [85, 123, 191] or glioneuronal tumors (5%) [191, 47, 49], BRAF p.V600E is less common.