In addition, intracytoplasmic neuronal inclusions were highlighted in the hippocampal subiculum and amygdala by immunohistochemistry for TDP-43 (Fig. 3e-f), while neocortical areas were devoid of TDP-43 pathology, corresponding to stage 2 of the recently defined limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC [41]). This evidence concerns the gene TARDBP and Encephalopathy.