Overall, the pooled results based on the whole population revealed significant correlation between VEGF rs2010963 variation and decreased PCOS susceptibility under 2 gene comparison models (Dominant model: OR = 0.78, 95%CI: 0.65–0.94, P = 0.008, I2 = 49%; Heterozygote model: OR = 0.75, 95%CI: 0.61–0.91, P = 0.04, I2 = 48%). This evidence concerns the gene VEGFA and polycystic ovary syndrome.