Most of the T2D risk was explained by the IGF/IGFBP system pathway (represented by IGFBP-2, 30%), followed by the adipose-derived hormone pathway (represented by adiponectin, leptin, and resistin, 22%) and the hormone regulation pathway (represented by sex hormone binding globulin (SHBG), 16%). Here, RETN is linked to type 2 diabetes mellitus.