For T2D, the adipose-derived hormone leptin (HR per SD = 2.75 [95% CI 2.31; 3.26]), the hemostasis marker tissue plasminogen activator (t-PA; 2.48 [2.16; 2.86]), and the insulin-like growth factor (IGF) binding protein 2 (IGFBP-2) (0.42 [0.37; 0.49]) demonstrated the strongest associations. The gene discussed is LEP; the disease is type 2 diabetes mellitus.