Dali et al. reported that binding of YTHDF1 to the transcripts encoding lysosomal proteases modified by m6A methylation improved the translational efficiency of lysosomal cathepsins in dendritic cells (DCs), while suppression of cathepsins in DC significantly strengthened its ability to cross-present tumor antigens, which in turn enhanced tumor infiltrating CD8+ T cell antitumor response. This evidence concerns the gene YTHDF1 and neoplasm.