CML: chronic myelocytic leukemia, AML: acute myelocytic leukemia, AML MLL: acute myelocytic leukemia with mixed lineage leukemia, CLL: chronic lymphocytic leukemia, ALL: acute lymphoblastic leukemia, MDS: myelodysplastic syndromes. The gene discussed is KMT2A; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.