SOCS3 and coronary artery disorder: Five hub genes (SOCS3, JUN, TNF, CXCL8, and TNFAIP3) were identified following GO functional enrichment analysis, KEGG pathway enrichment analysis, PPI network construction and MCODE analysis, but only four genes (SOCS3, TNF, CXCL8, and TNFAIP3) were verified by RT-qPCR in our CAD or IS patients.