Therefore, in the present research, we integrated and analysed two different CAD datasets and an IS dataset, identified 20 common DEGs to further and analysed their KEGG pathways, GO functional enrichment, and PPI networks and modules to define five significantly DEGs (CXCL8, TNF, SOCS3, TNFAIP3, and JUN). Here, TNFAIP3 is linked to coronary artery disorder.