Unconditional logistic regression analysis revealed that the overexpression of CXCL8, SOCS3, TNF and TNFAIP3, hyperlipidaemia, smoking and diabetes were considered independent risk factors for the incidence of CAD or IS; the incidence of IS was also positively correlated with hypertension, and the incidence of CAD was negatively correlated with alcohol consumption (Fig. 7). This evidence concerns the gene SOCS3 and hypertensive disorder.