Five hub genes (SOCS3, JUN, TNF, CXCL8, and TNFAIP3) were identified following GO functional enrichment analysis, KEGG pathway enrichment analysis, PPI network construction and MCODE analysis, but only four genes (SOCS3, TNF, CXCL8, and TNFAIP3) were verified by RT-qPCR in our CAD or IS patients. This evidence concerns the gene CXCL8 and coronary artery disorder.