Five hub genes (SOCS3, JUN, TNF, CXCL8, and TNFAIP3) were identified following GO functional enrichment analysis, KEGG pathway enrichment analysis, PPI network construction and MCODE analysis, but only four genes (SOCS3, TNF, CXCL8, and TNFAIP3) were verified by RT-qPCR in our CAD or IS patients. The gene discussed is TNF; the disease is coronary artery disorder.