Also, nuclear factor kappa B (NF-κB), tumor necrosis factor a (TNF-a), interleukin 1 a (IL-1a), interleukin 22 (IL-22), toll-like receptor 2 (TLR-2), toll-like receptor 4 (TLR-4), toll-like receptor 9 (TLR-9), interferon alpha (IFNA), interferon gamma (IFNG), and retinoic acid inducible gene 1 (RIG-1) are genetic risk factors involved in the pathogenesis of IIM [32]. This evidence concerns the gene TLR4 and acquired idiopathic inflammatory myopathy.