Nevertheless, inhibition of the TLR4 signaling adaptor molecules such as MyD88, Toll/IL-1 receptor (TIR) domain-containing adaptor protein (TIRAP), TRIF, TIR domain-containing adaptor molecule (TICAM-1) and TRIF-related adaptor molecule (TRAM)/TICAM-2 would result in immunodeficiency since these adaptors are shared by other TLRs [60]. This evidence concerns the gene TIRAP and immunodeficiency disease.