Likewise, in the murine model of myositis induced by immunization with myosin binding protein (C-MBP) and the antibody fusion protein (MYBPC2-MBP), an over-expression of TLR4 and its ligand, the high mobility group box 1 (HMGB1), has been found in muscle biopsies, and it correlated with the expression of major histocompatibility complex I (MHC-I), a key histopathologic finding of inflammatory myopathies [54]. Here, TLR4 is linked to myositis disease.