We now describe (i) analysis of the expression of sialylated glycans and sialidases in bladder cancer cells in comparison to normal bladder epithelial cells, using quantitative glycomics analysis and SILAC (stable isotope labeling by amino acids in cell culture) technique, (ii) evaluation of aberrant NEU1 expression and its functional role in apoptosis and proliferation of bladder cancer cells, and (iii) suppression of human bladder cancer by NEU1 in vitro and in vivo. This evidence concerns the gene NEU1 and urinary bladder carcinoma.