In addition, immunohistochemistry of tumor tissue from BALB/c-nu mice injected with YTS-1/NEU1 cells showed significant higher NEU1 expression, lower sialic acid modification (stained by lectin SNA and MAL-II) and lower FN-integrin α5β1 expression, compared to the tumor from the mice injected with YTS-1/Ctrl cells (Fig. 6g). This evidence concerns the gene FN1 and neoplasm.